GREEN BAY, Wis (WSAU-TSN)  The Packers season got off to a disappointing start on Sunday.

David Akers made three field goals, including an NFL record-tying 63-yarder, as the San Francisco 49ers made a strong case as the team to beat in the NFC with a 30-22 win at Lambeau Field.

The Packers had won 13 straight regular season home games, but rarely resembled the juggernaut that amassed a franchise-record 560 points during last year's 15-1 campaign.

Rather, it was the 49ers who showed last season's 13-3 record and run to the conference championship game was no fluke.

Alex Smith threw for 211 yards and two touchdowns on 20-of-26 efficiency for San Francisco (1-0), which had lost nine straight meetings with the Packers (0-1).

Randy Moss, signed in the offseason after retiring for a year, caught four passes for 47 yards and a TD, while Frank Gore ran for 112 yards and a score on 16 carries in the win.

Aaron Rodgers, the reigning league MVP, tossed for 303 yards with two touchdowns and one interception while completing 30-of-44 attempts.

Randall Cobb totaled 77 yards on a team-high nine catches and returned a punt 75 yards for a TD with 11:16 remaining in a highlight-filled fourth quarter.

The Packers play again Thursday night against the Bears.