The Twins star and Perlman announced their separation after 30 years of marriage on Monday (08Oct12).
No reason was given for the break-up, but an article in the new issue of the National Enquirer alleges the Cheers actress called time on the relationship after reportedly discovering her husband had been cheating on her.
Enquirer editors claim DeVito was rumoured to have enjoyed a fling with another woman while starring in a London stage production of The Sunshine Boys over the summer (12).
However, the former couple's spokesman, Stan Rosenfield, insists no third party was involved in their decision to part ways.
He states, ""Whatever you may read is a fabrication. Nobody knows the real reason (for the split) because they have not shared it with anyone.""