The upcoming comedy, 50/50, handles a sensitive subject with a little more humor than we're used to. Joseph Gordon-Levitt plays a man diagnosed with cancer who's struggling to deal with this realization and Seth Rogen is his wise-cracking best friend. This clip in which Gordon-Levitt finally tells Rogen about his condition just confirms our suspicions about the film from the first trailer we saw: this could be Summit's next big thing. The film hits theaters September 30 and promises to be a heartfelt, grounded look at something that most of us like to pretend isn't plaguing members of the population.

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